Hello, I installed Galaxy on a new Mac Pro with 64gb of ram and a solid state first drive and 3 , 2tb normal drives. I can upload from my desktop a smaller file like a reference list or a cuffdiff file but when I try to load a 16gb fastq file it just does not load. Given that I have my files on the same computer that has Galaxy, and given that I am not well versed in unix, would anyone have a suggestion as to ways I could easily upload these large files. I would like to think I am just naive and that this has a simple solution. Hopefully this is the correct list to pose this question. Thank you for any help, el linney For those in the no, I did see this appear on the terminal after I tried to upload the file through the browser mechanism for upload: "Overflow Error: signed integer is greater than maximum"