are there plans to address this issue or is this not affecting others besides Michael and myself? This is currently a complete blocker for me: - downloading large files from Galaxy fails with an out of memory error - trying to fix that by setting debug = False causes galaxy to be unusable. The application starts up, but the History panel shows 'internal server error' and the app throws a RuntimeError: Traceback (most recent call last): File "/home/galaxy/galaxy_dist/eggs/Paste-1.6-py2.6.egg/paste/httpserver.py", line 1053, in process_request_in_thread self.finish_request(request, client_address) File "/usr/lib/python2.6/SocketServer.py", line 320, in finish_request self.RequestHandlerClass(request, client_address, self) File "/usr/lib/python2.6/SocketServer.py", line 615, in __init__ self.handle() File "/home/galaxy/galaxy_dist/eggs/Paste-1.6-py2.6.egg/paste/httpserver.py", line 432, in handle BaseHTTPRequestHandler.handle(self) File "/usr/lib/python2.6/BaseHTTPServer.py", line 329, in handle self.handle_one_request() File "/home/galaxy/galaxy_dist/eggs/Paste-1.6-py2.6.egg/paste/httpserver.py", line 427, in handle_one_request self.wsgi_execute() File "/home/galaxy/galaxy_dist/eggs/Paste-1.6-py2.6.egg/paste/httpserver.py", line 290, in wsgi_execute self.wsgi_write_chunk(chunk) File "/home/galaxy/galaxy_dist/eggs/Paste-1.6-py2.6.egg/paste/httpserver.py", line 125, in wsgi_write_chunk "Content returned before start_response called") RuntimeError: Content returned before start_response called I did an update of galaxy, migrated the database to version 58, and am still unable to switch off debugging. Galaxy is not running behind apache at present. Without the ability to download large-ish files, I am losing support to have Galaxy in production *sob*. Any help greatly appreciated. Isabelle