Hi, I also have problems with macs and macs2 after update. I got this error which seems a python version issue. But I can not find this file. File "cheetah_DynamicallyCompiledCheetahTemplate_1394672664_28_93644.py", line 82, in respond ImportError: No module named simplejson Any suggestions? Thanks a lot. Changyu Traceback (most recent call last): File "/ifs/rcgroups/webapps/galaxy/rcapps/rcapps-galaxy-dist03/lib/galaxy/jobs/runners/__init__.py", line 152, in prepare_job job_wrapper.prepare() File "/ifs/rcgroups/webapps/galaxy/rcapps/rcapps-galaxy-dist03/lib/galaxy/jobs/__init__.py", line 697, in prepare config_filenames = self.tool.build_config_files( param_dict, self.working_directory ) File "/ifs/rcgroups/webapps/galaxy/rcapps/rcapps-galaxy-dist03/lib/galaxy/tools/__init__.py", line 2757, in build_config_files f.write( fill_template( template_text, context=param_dict ) ) File "/ifs/rcgroups/webapps/galaxy/rcapps/rcapps-galaxy-dist03/lib/galaxy/util/template.py", line 9, in fill_template return str( Template( source=template_text, searchList=[context] ) ) File "/ifs/rcgroups/webapps/galaxy/rcapps/rcapps-galaxy-dist03/eggs/Cheetah-2.2.2-py2.7-linux-x86_64-ucs2.egg/Cheetah/Template.py", line 1004, in __str__ return getattr(self, mainMethName)() File "cheetah_DynamicallyCompiledCheetahTemplate_1394672664_28_93644.py", line 82, in respond ImportError: No module named simplejson