I have galaxy running on my institution's cluster computing service, which uses PBS. It's in a balanced configuration. Jobs going to the cluster submit without any problem at all. However, any job that I have specified to run locally in the universe_wgsi.ini file won't dispatch. There isn't any record of the job in the manager.log, or any of the handler[#].log files. In fact, I've never seen anything in the handler logfiles after "serving on [GALAXY IP]:[SPECIFIC PORT NUMBER OF HANDLER]". The manager logfile has all the details about the jobs dispatched to the pbs runner, but nothing about local jobs. HOWEVER, if I stop Galaxy using "GALAXY_RUN_ALL=1 sh ./run.sh --stop-daemon" and restart using "GALAXY_RUN_ALL=1 sh ./run.sh --daemon" then the local jobs that were waiting to run begin immediately. Information about them shows up in manager.log, but not in the handler0.log or handler1.log files. I'm on an 8-core Dell R410 server, if that matters. The server portion of my universe_wsgi.ini file is pasted below. # ---- HTTP Server ---------------------------------------------------------- # Configuration of the internal HTTP server. [server:web0] # The internal HTTP server to use. Currently only Paste is provided. This # option is required. use = egg:Paste#http # The port on which to listen. port = 8080 # The address on which to listen. By default, only listen to localhost (Galaxy # will not be accessible over the network). Use '0.0.0.0' to listen on all # available network interfaces. host = localhost # Use a threadpool for the web server instead of creating a thread for each # request. use_threadpool = True # Number of threads in the web server thread pool. threadpool_workers = 7 [server:web1] use = egg:Paste#http port = 8081 host = localhost use_threadpool = true threadpool_workers = 7 [server:manager] use = egg:Paste#http port = 8079 host = localhost use_threadpool = true threadpool_workers = 5 [server:handler0] use = egg:Paste#http port = 8090 host = localhost use_threadpool = true threadpool_workers = 5 [server:handler1] use = egg:Paste#http port = 8091 host = localhost use_threadpool = true threadpool_workers = 5 [app:main] # -- Application and filtering job_manager = manager job_handler = handler0,handler1 # ---- Custom Parameters ----------------------------------------------------