For information, here is my install script for rpy, because I had to reinstall all of that on CentOS 5.4... :

#!/bin/bash
#
#

#

echo "< RPY for R and Python **********************************"

cd rpy;

export LD_LIBRARY_PATH=/opt/gridengine/lib/lx26-amd64:/lib64:/usr/lib64:/usr/local/lib64:/usr/lib/:/usr/local/lib/
#export R_HOME=/usr/lib64/R/

# remy modifications 17/01/2012
unset R_HOME

export RHOME=/usr/lib64/R/

cp -s /usr/lib64/R/lib/* /usr/lib64/R/bin/

# rajout 17/01/2012
mkdir -p /usr/share/R/include

cp -s /usr/lib64/R/include/* /usr/share/R/include/
cp -s /usr/lib64/R/include/* /usr/local/include/
cp -s /usr/lib64/R/include/* /usr/include/
cp -s /usr/lib64/R/lib/* /usr/lib/
cp -s /usr/lib64/R/lib/* /lib64/
cp -s /usr/lib64/R/lib/* /usr/local/lib64/
cp -s /usr/lib64/R/lib/* /usr/local/lib/

ldconfig

cd trunk/rpy

sed -i "s/libraries=\['R'\]/libraries=\['R','Rlapack'\]/g" setup.py
# added 17/01/2012
sed -i "s|/usr/share/R/include|/usr/lib64/R/include/|g" setup.py
# added 17/01/2012
sed -i 's|\[0-9]+\\\.\[0-9]+\\\.\[0-9]+|[0-9]\.[0-9]+\.[0-9]|g' rpy_tools.py

python setup.py install

If it does not work, try with R_HOME.

2011/11/25 Oleksandr Moskalenko <om@hpc.ufl.edu>

On Nov 25, 2011, at 6:52 AM, Ivan Merelli wrote:

Hi,

I'm trying to use rgenetics in galaxy, but I have
some problem in installting rpy-1.0.3 with R-2.13.1.

I found this guide, which is about the same problem of mine:
http://gmod.827538.n3.nabble.com/Rpy-1-0-3-and-R-2-13-1-td3359590.html

but didn't work for me (although the part about the
modulefile is quite obscure for me). The problem seems
to be correlated to an header file (Rdevices.h) which
is no more present in the latest R distribution.

Any hints to solve this
problem? May I use rpy2?

Best,
Ivan

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There is information on solving this available via a web search - http://www.mail-archive.com/rpy-list@lists.sourceforge.net/msg01500.html for instance. In short,
Unpack rpy-1.0.3 and patch the following files:
rpm_tools.py
   version = re.search(" +([0-9]\.[0-9]+\.[0-9])", output)
setup.py
include_dirs = [ os.path.join(RHOME.strip(), 'include'),                        
       'src', '/usr/share/R/include', '/apps/R/2.13.1/include' ]
* Build rpy with 
python setup.py install
Cheers,

Alex
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