Hi, My problem was due to an old configuration in my galaxy.ini file. I had the following setting in my .ini but the correct setting earlier in the .ini file. nginx_x_accel_redirect_base = true I also had: location /_x_accel_redirect/ { internal; root /; } Instead of: location /_x_accel_redirect/ { internal; alias /; } In my nginx.conf file. The alias directive needs to be there or the value in nginx_x_accel_redirect_base gets placed in front of the download directory. Hopefully this helps someone else. Thanks, -Sheldon From: Briand, Sheldon (NRC/CNRC) Sent: Wednesday, February 15, 2017 2:01 PM To: 'galaxy-dev@lists.galaxyproject.org' <galaxy-dev@lists.galaxyproject.org> Subject: nginx x-accel Hi, I have galaxy 16.10. Whenever I try to download a file now nothing happens. I have followed the configuration guide for nginx to allow it to handle file downloads. However the nginx logs show that the file path has /etc/nginx/htmlTrue in front of the correct path. Obviously I have a misconfiguration somewhere but I am not sure what the problem is. Could someone point me in the right direction? Thanks, -Sheldon Sheldon Briand Computer Systems and Applications Analyst National Research Council/Government of Canada Sheldon.briand@canada.ca/<mailto:Sheldon.briand@canada.ca/> Tel: (902) 426-1677