ProgrammingError: (ProgrammingError) You must not use 8-bit bytestrings unless you use a text_factory that can interpret 8-bit bytestrings (like text_factory = str). It is highly recommended that you instead just switch your application to Unicode strings. u'UPDATE job SET update_time=?, state=?, stdout=?, stderr=? WHERE job.id = ?' ['2013-01-14 07:17:20.417990', 'error', '', '\n\n\x1b[33mS\x1b[0megmented \x1b[33mHAP\x1b[0mlotype \x1b[33mE\x1b[0mstimation & \x1b[33mI\x1b[0mmputation \x1b[33mT\x1b[0mool\ That is just a sample of the stderr from the galaxy stack trace. I think that shapeit is using 8 bit character codes in the stdout and galaxy is failing on adding to the database. Has anyone experienced this problem and could help me. Cheers James