[galaxy-dev] Connecting Galaxy to multiple Remote Clusters?

Hello, I've read through past emails that connecting Galaxy to a remote cluster is possible but I wanted to ask if it was possible to setup Galaxy as a standalone webserver and have it use multiple remote clusters (multiple head nodes each with their own compute nodes) and if so what the best strategy to implement this is? Also on one of these clusters we are not able to mount an NFS directory onto the compute nodes, since we do not own/manage it. Your help is greatly appreciated. Thanks, Joe