Thanks for the feedback. I cannot seem to find information for hmmdb.loc. When I look in the associated xml file it looks like it could be removed completely (does one need a precompiled HMM Database? I do not remember using anything like this when I run hmmer on the commandline). I have less experience with changing wrappers, etc. Have you tried just commenting this part out? And do I need to start the instance over to test it?
<conditional name="hmmdb">
<param name="select" type="select" label="HMM Db">
<option value="db" selected="True">Precompiled HMM Database</option>
<option value="user">HMM Database in your History</option>
</param>
<when value="db">
<param name="file" type="select" label="Precompiled HMM database">
<options from_file="hmmdb.loc">
<column name="name" index="1"/>
<column name="value" index="2"/>
</options>
</param>
</when>
<when value="user">
<param name="file" type="data" format="hmmer" label="HMM database" />
</when>
</conditional>