Hi Greg,Thanks for the feedback. I cannot seem to find information for hmmdb.loc. When I look in the associated xml file it looks like it could be removed completely (does one need a precompiled HMM Database? I do not remember using anything like this when I run hmmer on the commandline). I have less experience with changing wrappers, etc. Have you tried just commenting this part out? And do I need to start the instance over to test it?Thanks in advance!- Karen<conditional name="hmmdb"><param name="select" type="select" label="HMM Db"><option value="db" selected="True">Precompiled HMM Database</option><option value="user">HMM Database in your History</option></param><when value="db"><param name="file" type="select" label="Precompiled HMM database"><options from_file="hmmdb.loc"><column name="name" index="1"/><column name="value" index="2"/></options></param></when><when value="user"><param name="file" type="data" format="hmmer" label="HMM database" /></when></conditional>