Hey all; Nate, many thanks for the updated wiki documentation on configuring nginx. Awesome stuff, with the help of this I've been able to get nginx handling uploads on our local galaxy server. I added some notes to the documentation about getting this running with a prefix, and also submitted a patch which sorts out some redirect issues with both nginx and a prefix: http://bitbucket.org/galaxy/galaxy-central/issue/366/uploads-from-tool-menu-... There's one issue related to uploading through nginx that I could use some advice on. Uploading larger (>1M) files was giving a 413 error, which appeared to be related to the client_max_body_size parameter: http://forum.slicehost.com/comments.php?DiscussionID=1714 Resetting client_max_body_size to a value larger than the upload file resolved the problem. Is this how you handle large file uploads on Galaxy main or is there a better way? If that's the right solution I can add a note to the wiki docs for future nginx users, but am not confident enough in my nginx skillz to start passing out advice without a bit of confirmation. Thanks much, Brad