This is something I am very interested in. The three parts below make sense to me. I would be very happy to discuss further and provide any help to move this forward.

On Oct 26, 2013, at 2:43 PM, Kyle Ellrott <> wrote:

I think one of the aspects where Galaxy is a bit soft is the ability to do distributed tasks. The current system of split/replicate/merge tasks based on file type is a bit limited and hard for tool developers to expand upon. Distributed computing is a non-trival thing to implement and I think it would be a better use of our time to use an already existing framework. And it would also mean one less API for tool writers to have to develop for.
I was wondering if anybody has looked at Mesos ( ). You can see an overview of the Mesos architecture at
The important thing about Mesos is that it provides an API for C/C++, Java/Scala and Python to write distributed frameworks. There are already implementations of frameworks for common parallel programming systems such as:
 - Hadoop (
 - MPI (
 - Spark (
And you can find example Python framework at

Integration with Galaxy would have three parts:
1) Add a system config variable to Galaxy called 'MESOS_URL' that is then passed to tool wrappers and allows them to contact the local mesos infrastructure (assuming the system has been configured) or pass a null if the system isn't available. 
2) Write a tool runner that works as a mesos framework to executes single cpu jobs on the distributed system.
3) For instances where mesos is not available at a system wide level (say they only have access to an SGE based cluster), but the user wants to run distributed jobs, write a wrapper that can create a mesos cluster using the existing queueing system. For example, right now I run a Mesos system under the SGE queue system.

I'm curious to see what other people think.

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Ravi K Madduri
MCS, Argonne National Laboratory
Computation Institute, University of Chicago