[galaxy-dev] Local galaxy of release_18.05 is too slow

Hi list, I use Anaconda2-5.2.0-Linux-x86_64.sh and galaxy release_18.05 for my local galaxy, but I found it was too slow to open the web pages. The release_17.09 on the same server is much faster. I can see some limit when release_18.05 start: your processes number limit is 4096 your memory page size is 4096 bytes detected max file descriptor number: 65535 !!! no /etc/mime.types file found !!! lock engine: pthread robust mutexes Is this related to my problem? or which options could I set ? Thank you. Steven