I had a similar issue a while ago. Greg mentioned the following setting in universe:

# Enable use of an in-memory registry with bi-directional relationships
# between repositories (i.e., in addition to lists of dependencies for a
# repository, keep an in-memory registry of dependent items for each repository.
#manage_dependency_relationships = True


Setting this to false made the delay go away. I haven't had issues so far after disabling.

See here for details: http://lists.bx.psu.edu/pipermail/galaxy-dev/2014-March/018821.html

Best,

Geert


On 08/05/2014 09:01 PM, Dannon Baker wrote:
There's definitely a request that will occasionally block at startup -- I've hit this before too, Martin.  Looking into it now.


On Tue, Aug 5, 2014 at 2:59 PM, Martin Čech <marten@bx.psu.edu> wrote:
I just freshly cloned galaxy-central, switched to next-stable and did initial startup - no problems detected and Galaxy booted in under 2m.


On Tue, Aug 5, 2014 at 2:54 PM, Langhorst, Brad <Langhorst@neb.com> wrote:
I’ve noticed that startup is very slow.

It’s about 15 minutes for me to stop and restart my 4 daemons.
It was much faster with galaxy on local storage.

brad
--
Bradley W. Langhorst, Ph.D.
Applications and Product Development Scientist

On Aug 5, 2014, at 2:41 PM, Björn Grüning <bjoern.gruening@gmail.com> wrote:

Hi all,

does anyone encountered a long start-up delay with the recent next-stable and starting a instance from scratch?

For me its hanging at:

tool_shed.galaxy_install.migrate.check DEBUG 2014-08-05 18:39:45,207 psycopg2 egg successfully loaded for postgres dialect

for 3-5 minutes.

Cheers,
Bjoern
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-- 

Geert Vandeweyer, Ph.D.
Department of Medical Genetics
University of Antwerp
Prins Boudewijnlaan 43
2650 Edegem
Belgium
Tel: +32 (0)3 275 97 56
E-mail: geert.vandeweyer@ua.ac.be
http://ua.ac.be/cognitivegenetics
http://www.linkedin.com/in/geertvandeweyer