I think this error most commonly occurs when a virtualenv is used with a different python than the one it was created with. Is the cluster also running Ubuntu 14.04? If not, you can create a separate virtualenv for running tools using the instructions at:

https://docs.galaxyproject.org/en/master/admin/framework_dependencies.html#managing-dependencies-manually

Once created, your tools can use it by setting `<param id="GALAXY_VIRTUAL_ENV">/path/to/venv</param>` on the destination in job_conf.xml

--nate

On Thu, Jan 18, 2018 at 1:50 PM, Cao Tang <charlietang98@gmail.com> wrote:
You can try to install:

https://pypi.python.org/pypi/hashlib

On Thu, Jan 18, 2018 at 1:22 PM, John Letaw <letaw@ohsu.edu> wrote:
Thanks for the response Peter.  I currently have this instance installed on a lustre fs, that is visible on an Ubuntu 14.04 vm.  So, there very well may be mismatches between directories on the VM, and those on the lustre cluster.  This would mean the python installation on the VM needs to exactly match that which is on the cluster?  What else will need to match to ensure success?

Thanks,
John

On 1/18/18, 1:50 AM, "Peter Cock" <p.j.a.cock@googlemail.com> wrote:

    I *think* this is a problem with your copy of Python 2.7 and a
    standard library (hashlib) normally present. Do you know how this
    Python was installed? If it was compiled from source, then it may have
    been missing a few dependencies, and thus you have ended up with
    missing a few normally present Python modules.

    Peter

    On Wed, Jan 17, 2018 at 11:15 PM, John Letaw <letaw@ohsu.edu> wrote:
    > Hi all,
    >
    >
    >
    > I have been trying to finish up a production cluster Galaxy installation,
    > and am having trouble with the below error.  In the past, when seeing
    > something along these lines, I usually can adjust environmental variables
    > either in startup scripts, or by including a script for Galaxy to source
    > before it sends out a job.  I have tried all of these different methods, but
    > I can’t seem to get rid of this error message in any tool invocation.  I
    > currently have “embed_metadata_in_job” set to False in my job_conf.xml file.
    > This removes a “No module named galaxy_ext.metadata.set_metadata” error, but
    > this hashlib error remains.  If I could understand a little more about the
    > steps that are taken when sending out a job, perhaps I could better diagnose
    > this?
    >
    >
    >
    > “””
    >
    > Could not find platform dependent libraries
    >
    > Consider setting $PYTHONHOME to [:]
    >
    > Traceback (most recent call last):
    >
    >   File "~/galaxydev/galaxy/tools/data_source/upload.py", line 14, in
    >
    >     import tempfile
    >
    >   File "/usr/lib64/python2.7/tempfile.py", line 35, in
    >
    >     from random import Random as _Random
    >
    >  File "/usr/lib64/python2.7/random.py", line 49, in
    >
    >     import hashlib as _hashlib
    >
    >   File "/usr/lib64/python2.7/hashlib.py", line 116, in
    >
    >     import _hashlib
    >
    > ImportError: No module named _hashlib
    >
    > “””
    >
    >
    >
    > Thanks,
    >
    > John
    >
    >
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___________________________________________________________
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