Jochen We once had a similar, sudden performance problem, and found that the setting Galaxy.ini: debug = False Had accidentally been re-set to "True". Having "debug" turned on really, really slows down the galaxy app process.... So, check that debug = False. Regards Curtis -----Original Message----- From: galaxy-dev [mailto:galaxy-dev-bounces@lists.galaxyproject.org] On Behalf Of Jochen Bick Sent: Friday, December 9, 2016 6:05 AM To: galaxy-dev@lists.galaxyproject.org Subject: [galaxy-dev] Speedup Galaxy We are running a Galaxy instance at our institute (version 15.10). Since some month the speed/reaction time of the interface drastically decrease. Sometimes there is a lack of more than a minute loading a single tool. I restarted galaxy without any improvements. We are working with up to 3 people on this instance that should not be the problem. Does anyone have any idea? Disk-space? uptime of our server? big full database? ?? Cheers Jochen ___________________________________________________________ Please keep all replies on the list by using "reply all" in your mail client. To manage your subscriptions to this and other Galaxy lists, please use the interface at: https://lists.galaxyproject.org/ To search Galaxy mailing lists use the unified search at: http://galaxyproject.org/search/mailinglists/