Dear all, I've been trying to set up a Galaxy instance on my CentOS server but even when I manage to run the simplest configuration correctly I can't seem to get it right on my browser as the connection is refused. I have changed the host to 0.0.0.0, the port to 8081 and made the appropriate changes in Apache configuration file: RewriteEngine on RewriteRule ^/galaxy_test(.*) http://localhost:8081$1 [P] RewriteRule ^/galaxy_test$ /galaxy_test/ [R] RewriteRule ^/galaxy_test/static/style/(.*) /home/galaxy_test/galaxy/static/june_2007_style/blue/$1 [L] RewriteRule ^/galaxy_test/static/scripts/(.*) /home/galaxy_test/galaxy/static/scripts/packed/$1 [L] RewriteRule ^/galaxy_test/static/(.*) /home/galaxy_test/galaxy/static/$1 [L] RewriteRule ^/galaxy_test/favicon.ico /home/galaxy_test/galaxy/static/favicon.ico [L] RewriteRule ^/galaxy_test/robots.txt /home/galaxy_test/galaxy/static/robots.txt [L] So when I tried to run it the first time I got the "temporarily out of service" error on my browser and the following error in apache log: [Mon Oct 19 05:56:45.308714 2015] [proxy:error] [pid 18505] (13)Permission denied: AH00957: HTTP: attempt to connect to 127.0.0.1:8081 (*) failed [Mon Oct 19 05:56:45.308774 2015] [proxy_http:error] [pid 18505] [client 185.25.151.159:39629] AH01114: HTTP: failed to make connection to backend: localhost Searching the internet I found the following solution: /usr/sbin/setsebool httpd_can_network_connect 1 /usr/sbin/setsebool -P httpd_can_network_connect 1 but when I restarted my galaxy my browser would now show just a blank page and the error log of apache was: [Mon Oct 19 15:29:09.425120 2015] [proxy:error] [pid 29699] (111)Connection refused: AH00957: HTTP: attempt to connect to 127.0.0.1:8081 (*) failed [Mon Oct 19 15:29:09.425167 2015] [proxy_http:error] [pid 29699] [client 147.102.86.121:51865] AH01114: HTTP: failed to make connection to backend: localhost Has anyone encountered that? Kind regards, Makis P.S. In case that helps the output of iptables -L is the following: Chain INPUT (policy ACCEPT) target prot opt source destination ACCEPT all -- anywhere anywhere ctstate RELATED,ESTABLISHED ACCEPT all -- anywhere anywhere INPUT_direct all -- anywhere anywhere INPUT_ZONES_SOURCE all -- anywhere anywhere INPUT_ZONES all -- anywhere anywhere ACCEPT icmp -- anywhere anywhere REJECT all -- anywhere anywhere reject-with icmp-host-prohibited Chain FORWARD (policy ACCEPT) target prot opt source destination ACCEPT all -- anywhere anywhere ctstate RELATED,ESTABLISHED ACCEPT all -- anywhere anywhere FORWARD_direct all -- anywhere anywhere FORWARD_IN_ZONES_SOURCE all -- anywhere anywhere FORWARD_IN_ZONES all -- anywhere anywhere FORWARD_OUT_ZONES_SOURCE all -- anywhere anywhere FORWARD_OUT_ZONES all -- anywhere anywhere ACCEPT icmp -- anywhere anywhere REJECT all -- anywhere anywhere reject-with icmp-host-prohibited Chain OUTPUT (policy ACCEPT) target prot opt source destination OUTPUT_direct all -- anywhere anywhere Chain FORWARD_IN_ZONES (1 references) target prot opt source destination FWDI_public all -- anywhere anywhere [goto] FWDI_public all -- anywhere anywhere [goto] Chain FORWARD_IN_ZONES_SOURCE (1 references) target prot opt source destination Chain FORWARD_OUT_ZONES (1 references) target prot opt source destination FWDO_public all -- anywhere anywhere [goto] FWDO_public all -- anywhere anywhere [goto] Chain FORWARD_OUT_ZONES_SOURCE (1 references) target prot opt source destination Chain FORWARD_direct (1 references) target prot opt source destination Chain FWDI_public (2 references) target prot opt source destination FWDI_public_log all -- anywhere anywhere FWDI_public_deny all -- anywhere anywhere FWDI_public_allow all -- anywhere anywhere Chain FWDI_public_allow (1 references) target prot opt source destination Chain FWDI_public_deny (1 references) target prot opt source destination Chain FWDI_public_log (1 references) target prot opt source destination Chain FWDO_public (2 references) target prot opt source destination FWDO_public_log all -- anywhere anywhere FWDO_public_deny all -- anywhere anywhere FWDO_public_allow all -- anywhere anywhere Chain FWDO_public_allow (1 references) target prot opt source destination Chain FWDO_public_deny (1 references) target prot opt source destination Chain FWDO_public_log (1 references) target prot opt source destination Chain INPUT_ZONES (1 references) target prot opt source destination IN_public all -- anywhere anywhere [goto] IN_public all -- anywhere anywhere [goto] Chain INPUT_ZONES_SOURCE (1 references) target prot opt source destination Chain INPUT_direct (1 references) target prot opt source destination Chain IN_public (2 references) target prot opt source destination IN_public_log all -- anywhere anywhere IN_public_deny all -- anywhere anywhere IN_public_allow all -- anywhere anywhere Chain IN_public_allow (1 references) target prot opt source destination ACCEPT tcp -- anywhere anywhere tcp dpt:http ctstate NEW ACCEPT tcp -- anywhere anywhere tcp dpt:ssh ctstate NEW ACCEPT tcp -- anywhere anywhere tcp dpt:https ctstate NEW Chain IN_public_deny (1 references) target prot opt source destination Chain IN_public_log (1 references) target prot opt source destination Chain OUTPUT_direct (1 references) target prot opt source destination