Hello, I tried restarting my local Galaxy instance today bit it won't start up properly. I keep getting this message when I run "sh run.sh": Traceback (most recent call last): File "/mnt/ris-fas1a/linux_users/avnglxy/ris-lx10/galaxy-dist/lib/galaxy/webapps/galaxy/buildapp.py", line 35, in app_factory app = UniverseApplication( global_conf = global_conf, **kwargs ) File "/mnt/ris-fas1a/linux_users/avnglxy/ris-lx10/galaxy-dist/lib/galaxy/app.py", line 79, in __init__ self.datatypes_registry.load_datatypes( self.config.root, self.config.datatypes_config ) File "/mnt/ris-fas1a/linux_users/avnglxy/ris-lx10/galaxy-dist/lib/galaxy/datatypes/registry.py", line 273, in load_datatypes self.to_xml_file() File "/mnt/ris-fas1a/linux_users/avnglxy/ris-lx10/galaxy-dist/lib/galaxy/datatypes/registry.py", line 681, in to_xml_file os.close( fd ) OSError: [Errno 5] Input/output error The reason for my restart was dur to a users complaint about upload speeds. Any help is much appreciated! Richard