I now have 2 versions of snpeff installed from the toolshed on my galaxy server. Each snpeff version includes an identical datatypes_conf.xml The galaxy server is setting metadata externally. When any job runs, (in may case I was running a picard tool), the following message is written to the job stderr: WARNING:galaxy.datatypes.registry:Overriding conflicting datatype with extension 'snpeffdb', using datatype from /galaxy/database/tmp/tmpdKGVnQ. Without stdio tags or otherwise catching the stderr, the job state is set to error. I'm now assuming that best practice would be to put the datatypes in a separate toolshed repository that would be a dependency for the tools repository. Thus the datatypes would not loaded multiple times and avoid overrride conflicts. In the meantime, I have just commented out the warning message. Any other advice on this issue? Thanks, JJ -- James E. Johnson, Minnesota Supercomputing Institute, University of Minnesota