Dear Nate, I just run the first step and must use sudo to "wget" and it is ok. Otherwsie, I can't write (Cannot write to `virtualenv.py.1' (Success).) ------------------- kangtu@dscbc-compute:~/Downloads/galaxy-dist$ sudo wget http://bitbucket.org/ianb/virtualenv/raw/tip/virtualenv.py [sudo] password for kangtu: --2011-02-11 09:36:31-- http://bitbucket.org/ianb/virtualenv/raw/tip/virtualenv.py Resolving bitbucket.org... 207.223.240.182, 207.223.240.181 Connecting to bitbucket.org|207.223.240.182|:80... connected. HTTP request sent, awaiting response... 301 Moved Permanently Location: https://bitbucket.org/ianb/virtualenv/raw/tip/virtualenv.py[following] --2011-02-11 09:36:31-- https://bitbucket.org/ianb/virtualenv/raw/tip/virtualenv.py Connecting to bitbucket.org|207.223.240.182|:443... connected. HTTP request sent, awaiting response... 200 OK Length: unspecified [text/x-python] Saving to: `virtualenv.py.1' [ <=> ] 75,592 --.-K/s in 0.04s 2011-02-11 09:36:31 (1.74 MB/s) - `virtualenv.py.1' saved [75592] ------------------------------------------- When I checked the root folder of "galaxy-dist", and found: -rw-r--r-- 1 kangtu admin 75592 2011-01-27 02:38 virtualenv.py -rw-r--r-- 1 root root 75592 2011-02-11 09:40 virtualenv.py.1 -rw-r--r-- 1 kangtu admin 69811 2011-01-27 02:38 virtualenv.pyc Should I chang something for step b "python virtualenv.py --no-site-packages galaxy_env"? for example, "python virtualenv.py.1 --no-site-packages galaxy_env", or rename "python virtualenv.py.1" as "python virtualenv.py". Best Wishes, Yan