Hi, I've installed a local instance of Galaxy (on Ubuntu 16.04, python 2.7.12) and have run in to this exact problem (posted by Nikolaos Tur https://www.mail-archive.com/galaxy-dev@lists.galaxyproject.org/msg03955.htm... ) while trying to add naive_variant_caller tool. Naive_variant_caller can't install because these two dependency packages can't be installed. I basically get exactly the same error message that ends with "IOError: Could not build the egg." Unfortunately I'm very new to both Galaxy and Python (Taking Coursera Galaxy course at the moment) and I don't really understand the solution Nikolaos described about modifying the setup.py to use "setuptools" instead of "distribute". I don't even know where to find setup.py... Can anyone help me with step-by-step details as to how to solve this dependency problem? Much Thanks! -- Jennifer Hsieh PhD Neuroscience (student) Department of Psychiatry and Mental Health University of Cape Town Tell: +27 21 447 3157 Cell: +27 74 841 4761