Hi all After running the recommended update I am now on branch 17.09. As part of the update I set up a new virtual env running an additional python 2.7.6. My previous virtual env was running 2.6.6 which is a system requirement for Centos 6. All dependencies were installed and Galaxy starts fine, but no tools run. The error is always a variation of this: Could not find platform dependent libraries <exec_prefix> Consider setting $PYTHONHOME to <prefix>[:<exec_prefix>] Traceback (most recent call last): File "galaxy-dist/database/jobs_directory/000/418/418014/set_metadata_4LcsZv.py", line 1, in <module> from galaxy_ext.metadata.set_metadata import set_metadata; set_metadata() File "galaxy-dist/lib/galaxy_ext/metadata/set_metadata.py", line 19, in <module> import json ImportError: No module named json I put some debug output at the top of set_metadata.py and it is indeed running the correct python version from the virtual env. Needless to say I can import json just fine using that python version. Any ideas? Any help is greatly appreciated. Thanks Ulf -- Ulf Schaefer, PhD Bioinformatics Scientist Bioinformatics Unit - Infectious Disease Informatics National Infection Service Public Health England 61 Colindale Ave, London NW9 5EQ ulf.schaefer@phe.gov.uk http://www.gov.uk/phe Protecting and improving the nation’s health ************************************************************************** The information contained in the EMail and any attachments is confidential and intended solely and for the attention and use of the named addressee(s). It may not be disclosed to any other person without the express authority of Public Health England, or the intended recipient, or both. If you are not the intended recipient, you must not disclose, copy, distribute or retain this message or any part of it. This footnote also confirms that this EMail has been swept for computer viruses by Symantec.Cloud, but please re-sweep any attachments before opening or saving. http://www.gov.uk/PHE **************************************************************************