Hi In a bash shell, I define the path (needed both by Galaxy to find the right version of python and by tools that run on a cluster to find the executables) and some other global variables on the command line. The cluster jobs (LSF) inherit all these values. This is my line DRMAA_LIBRARY_PATH=/usr/local/lsf/7.0/linux2.6-glibc2.3-x86_64/lib/libdrmaa.so.1.0.4 PATH=/usr/bin:/software/solexa/bin:$PATH http_proxy="http://somecache:3128" sh run.sh Is there anything inherently wrong with this simple solution? Marina -- The Wellcome Trust Sanger Institute is operated by Genome Research Limited, a charity registered in England with number 1021457 and a company registered in England with number 2742969, whose registered office is 215 Euston Road, London, NW1 2BE.