I am launching instances with the brand new AMI, ami-118bfc78. The symlinks are broken for me. Is there an additional step I need to take after launching the instances? I feel like I am overlooking something.
Also, fixing bow tie along with top-hat did not fix the error. I will look into this further.
Is this a migrated cluster or a brand new one? I'm guessing you're using the new AMI?
The migration process supposed to have updated those env.sh paths.
More to the point, is your tophat job failing due to bowtie not being found? Try adding the path to bowtie executables to tophat's env.sh file as well and see if that fixes the issue.