Hello We found a problem when we execute a job in local mode with galaxy. When a job is running and galaxy restarted, we obtain this error : message: socket.error: [Errno 98] Address already in use All the file descriptors are passed from parent to child by default with subprocess.popen. If you want to close all file descriptors excepted stdin, stdout and stderr, you have to use the option: close_fds = True. In local.py line 84-90: proc = subprocess.Popen( args = command_line, shell = True, cwd = job_wrapper.working_directory, stdout = stdout_file, stderr = stderr_file, env = os.environ, preexec_fn = os.setpgrp, close_fds = True ) I hope this will help resolving this bug Thank you in advance. Sincerely Fabien Mareuil -- Fabien Mareuil | Centre d'Informatique pour la Biologie fabien.mareuil@pasteur.fr | Institut Pasteur 25,28 rue du Docteur Roux 75015 Paris, France