Dear community members, Now I try install Galaxy into our local servers, and I largely-successful run Galaxy at local server with Apache-proxy. However, I encounter problem in relation to xsendfile, the details of my configuration are shown below, 1. I Installed mod_xsendfile 2. set up universe_wsgi.ini [app:main] apache_xsendfile = True 3. set up httpd.conf <Location "/galaxy"> XsendFile on XsendFilePath /galaxy </Location> After above configuration, I restart Galaxy and run jobs (e.g. FastQC). However, when I click floppy icon to download the result file, the right history window go white background and shows following error message, "OK The requested URL /galaxy/datasets/1877a09319a433f5/ display was not found on this server." If I change the apache_xsendfile setting to False, I can download files as usual. Why I can not use xsenfile module? I would like to know some ideas for solution of this problem. Thank you very much in advance. kenichi