Hi Kathryn, Hopefully instructions here should help you out: http://wiki.galaxyproject.org/Admin/Config/Performance/ProductionServer#Use_... I've also cc'd the galaxy-dev list as that's the best place to ask questions like this instead of emailing team members directly. Using the list, you'll reach a larger audience who may be able to help you and at the same time the answer to your question can benefit others. Let me know if you have any more trouble, -Dannon Sun, Wenping [USA] wrote: Hi Dannon, The python at my server version is 2.4. I have installed python 2.7 and set link as well as path based on the guide. However, the default python version still remain unchanged and galaxy would not run. Would you mind providing some help on this? Thank you very much, Kathryn