Hi Galaxy, When I try to process my exome data bam files using DepthOfCoverage under GATK tools (on the main instance), the program seems to keep running forever without ever completing. There is no error message output but the program never ends after going for several days! Could it be something wrong with my files or has any one else reported having an issue with it? Regards, Tom --------------------------------------------- Thomas Jaworek Department of Ophthalmology Cincinnati Children's Hospital 3333 Burnet Avenue Research Building R2409 Cincinnati, OH 45229 thomas.jaworek@cchmc.org 513-803-2951