Dear Galaxy community, I'm currently testing cross-platform compatibility with our Galaxy instance (15.10) : - [on PROD environment] Galaxy service runs on a RedHat 6.5 server (using python2.6 installed in a virtualenv) and submits jobs on cluster nodes also in RedHat 6.5/python2.6 (default version installed on the system). - [on TEST environment] I changed the configuration of our Galaxy TEST instance (still RedHat 6.5 / python 2.6) to submit jobs on cluster nodes in CentOS7/python2.7 (default version installed on the system). - Galaxy installations (test and prod) and virtualenv folders are located in a volume mounted on Galaxy servers and all cluster nodes. On TEST environment python tools (like the internal Galaxy tool "upload1", or the NCBI BLAST toolkit) if submitted on the cluster failed with the following message : "python: error while loading shared libraries: libpython2.6.so.1.0: cannot open shared object file: No such file or directory" I guess the problem lies in the shared library libpython2.6.so.1.0 located in /usr/lib64/libpython2.6.so.1.0 on the Galaxy server and absent from the cluster nodes (it should be something like /usr/lib64/python2.7/libpython2.7.so.1.0). Is it possible to integrate this shared library in the Python virtualenv and use a specific configuration to indicate Galaxy to use it when submitting jobs on the cluster ? Thanks in advance, Floreline.