Galaxy imported a library which already existed in the python system folder. See the error message below. Is that because RedHat 6 used a "python-marksafe", but Galaxy installation program did not recognize it? Or Galaxy require a higher version of markupsafe module? /home/xxxxx/work/galaxy-dist/ lib/galaxy/__init__.py:79: UserWarning: Module markupsafe was already imported from /usr/lib64/python2.6/site-packages/markupsafe/__init__.pyc, but /home/xxxxx/work/galaxy-dist/eggs/MarkupSafe-0.12-py2.6-linux-x86_64-ucs4.egg is being added to sys.path self.check_version_conflict() The system package is python-markupsafe-0.9.2-4.el6.x86_64 Galaxy has a newer version, it is MarkupSafe-0.12-py2.6-linux-x86_64-ucs4.egg Any idea how to resolve this problem?