*A 2 and half years position in Computational Biology* is available at the
laboratory of Drosophila Genetics and Epigenetics (CNRS UMR 7622 –
University Pierre-et-Marie-Curie, Paris) in relation with a consortium of
four laboratories funded by the ANR (Plastisipi project).
*Key words*: Software development for NGS analysis, Galaxy integration,
Small RNA biogenesis and mechanisms of action, siRNAs, piRNAs, miRNAs.
We are looking for a dynamic candidate with a wide knowledge in computer
sciences and statistics. She/He will develop statistical and mathematical
procedures to analyze NGS sequencing datasets and implement them in a
Galaxy Framework dedicated to the consortium.
*Scientific project:* The Plastisipi project is aimed at studying how
modulation of the piRNA silencing pathway may regulate Transposable Element
repression along Drosophila germ cell differentiation, allowing an
appropriate balance between genome protection and genome plasticity.
Another exciting aspect of the project is to study the role of tRNAs – or
tRNAs derived Fragments (tRFs) – in piRNA biogenesis.
*Job description:* The successful candidate will participate in 1- managing
and mining the sequencing datasets generated by Plastisipi to profile
piRNAs, tRFs and mRNAs; 2- developing new visualization tools; 3-
developing new algorithms to analyze the piRNA signatures at genome-wide
level as well as their statistical significance. Depending on the candidate
profile, there is also an opportunity to work through a core computing
science approach at the development of Galaxy instance “stacks” that could
be easily spread into the community.
The ideal candidate holds a PhD degree in computational biology and is
experienced in Galaxy developments; however, this profile is not mandatory
and candidates with little background in biology but strong experience in
core computing sciences, computing infrastructures, mathematics and/or
statistics will be welcome too. He/she will collaborate closely with a
multi-disciplinary team of biologists and bioinformaticians. Excellent
communication, management and reporting skills are essential for this role.
• Experience in NGS sequencing dataset analysis
• Advanced knowledge of a least one OOP language
• Knowledge of Postgresql
• Experience in tool integration in the Galaxy framework
• Advanced use of R
• Good notions of cloud computing
• Rigour, autonomy and excellent relational and teamwork skills
*Contract Duration:* Available in January 2014 for two and half years
(starting date flexible)
*Salary:* Depending on qualifications and experience, based on CNRS salary
*Application*: Send CV, cover letter and two references to Christophe
Shortlisted candidates will be invited for an interview.
On line information: http://drosophile.org/GEDlab/?page_id=760
On line bibliographic references: http://drosophile.org/?page_id=92
Drosophila Genetics and Epigenetics
Laboratoire de Biologie du Développement
9, Quai St Bernard, Boîte courrier 24
75252 Paris Cedex 05
Tel +33 1 44 27 34 39
Fax +33 1 44 27 34 45
Mobile +33 6 68 60 51 50