I have installed a local instance of Galaxy as a one user in a Mac Pro desktop.  I got some valuable help from Dannon Baker regarding how to load large datasets into it.  However I noticed that the Upload file for this instance would only go up to the

Zebrafish Dec. 2008 (Zv8/danRer6) (danRer6) version of the zebrafish assembly while where as the online version went up to the newer assembly

zebrafish assembly               Jul. 2010 (Zv9/danRER7)


While I could download newer reference genome in the program from UCSC Main table browser
whenever the local instance offered alternatives for genomes it only went up the earlier version
(Zv8/danRer6) (danRer6) .

I went ahead anyway, groomed 4 x 16gb datasets but when it came to Tophat,

An error occurred with this dataset: Could not determine Tophat version /bin/sh: tophat: command not found Error indexing reference sequence /bin/sh: bowtie-build: command not found


Also, when I download from UCSC the most updated zebrafish genome reference sequence and use it for Tophat, I get the following error signal:

I don't know if this issue of assembly version is associated with my Tophat problem--the two Tophat screens I get from either the main Galaxy or my instance are attached for comparison:
my local instance does not give me a "Use built-in genome option" while the main Galaxy does

Any advice?

Elwood Linney
DUMC