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www.kerafast.com
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Glycofect is a new transfection reagent that
eliicits low cytoxicity
response coupled with high delivery
effciency and transgene expression.
Glycofect is a superior reagent for
primary cell transfection as compared to
leading lipid and polycation-based
products.
Glycofect is a cationic
carbohydrate-containing
synthetic polymer based on
poly-glycoamidoamine (PGAA) polymer library developed
by Dr. Theresa M. Reineke et al. These
polymers contain linkages that hydrolyse
upon endocytosis, thereby increasing
plasmid delivery and reducing
toxicity.
Click
here for more details...
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CustomerService@KeraFAST.com
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1-800-546-1760 (toll free)
or 1-617-336-3228
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References:
T.M. Reineke "PGAAs:
" Cationic Glycopolymers for DNA
Delivery" J. Polym. Sci. A: Polym. Chem. 2006,
44, 6895-6908.
Y. Liu, T.M. Reineke,
"Poly(glycoamidoamine)s for Gene
Delivery. Stability of Polyplexes and
Efficacy with Cardiomyoblast Cells"
Bioconjugate Chem. 2006, 17,
101-108.
Y. Liu, T.M. Reineke, "Degradation
of Poly(glycoamidoamine) DNA Delivery
Vehicles: Polyamide Hydrolysis at
Physiological Conditions Promotes DNA
Release." Biomacromolecules, 2010, 11,
316.
Y. Liu, T.M. Reineke, "Hydroxyl
Stereochemistry and Amine Number
wihin Poly(glycoamidoamine)s Affect
Intracellular DNA Delivery." J. Am. Chem.
Soc., 2005, 127,
3004
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