I have tried to use ftp to upload files to main.g2.bx.psu.edu but the jobs have been failing with:

421 service not available, remote server has closed connection

after about 1.5GB.

Isn’t ftp the way you are supposed to upload large files?  The file I am uploading is ~6GB in size. 

Gábor Bartha, Ph.D.
Director of Information Sciences
Synergenics, LLC
863 Mitten Rd., Suite 101
Burlingame, CA 94010
650-777-5202