Hello, I'm getting this problem a lot when I'm trying to intersect data sets. There errors are similar to: Skipped 4 invalid lines of 1st dataset, 1st line #19614: "chr10 135498863 135499333 chr10.6783 1000 + 0.4037 15.3 -1 236 ", problem: 536870912 is larger than the size of this BitSet (536870912). This is on the main public server with the hg19 genome while running "overlapping pieces of intervals" on pairs of datasets in the attached history. I've tried different format types, changing the strand, confirming that the provided files to not extend past end of chromosomes, to no avail. Public history: http://main.g2.bx.psu.edu/u/timreddy/h/unnamed-history Seems there was an error to this extent in the archives from 2009, but no response. Tx, Tim -- Timothy E. Reddy, Ph.D. Assistant Professor Department of Biostatistics and Bioinformatics Institute for Genome Sciences and Policy Duke University School of Medicine 919-684-3286 (lab) 919-564-9536 (cell) tim.reddy@duke.edu