Hi, We have deployed a local instance of Galaxy and have recently been experiencing several problems which we believe to be related to our server being overloaded with user requests. We get the following error message (from the log files): raise exc.TimeoutError("QueuePool limit of size %d overflow %d reached, connection timed out, timeout %d" % (self.size(), self.overflow(), self._timeout)) TimeoutError: QueuePool limit of size 10 overflow 20 reached, connection timed out, timeout 30 Could someone explain why we might get this error message and how we might configure our server settings to solve this problem? Is universe_wsgi.ini.sample a configuration for production server instances? If not, could someone post some suggested settings for production servers (e.g. the settings that you use for the main galaxy instance http://main.g2.bx.psu.edu/)? Finally, is there a wiki page explaining the settings in universe_wsgi.ini? Thanks, Len