Hi, Thank you for the very nice tool you are developping. I'm currently having some problems to run the standalone version of fastx_clipper on my own computer. Here is the bug report : fastx_clipper: failed to open input file 'path': Value too large for defined data type It seems like it's an error linker to gzip and files > 4Go but i don't see the point. Do you have a clue of what i could try to solve that. thank you Philippe Moncuquet IR Bioinformatician Olivier Pourquié's team IGBMC 1 rue Laurent Fries BP 10142 67404 Illkirch CEDEX / France Tél +33 (0) 3 88 65 33 98 pmcqt@igbmc.fr