When you say NGS, is it genome assembly? If so, what type of genomes and do you have experience with its memory and cpu requirements. We noted that servers with large amount of memory and cores have a memory bus bottleneck. The other aspect is high processing on the server will impact the performance of Galaxy unless it is given higher priority. Note that if you overcommit the server, it can destabilize and bring down the Galaxy web app and database.
My general approach is Galaxy web app + proxy on a separate machine from the handlers. The analysis server is either running a grid or the handlers.
I recommend multiple smaller servers if you can get away with it as long as you have one that can accommodate your LARGE workloads. If you don't care about overall performance, large servers are the way to go as they are more "versatile".
Regards,
Iyad Kandalaft
Acting Chief Bioinformatician in Biodiversity, STB Agriculture and Agri-Food Canada / Government of Canada Iyad.Kandalaft@Agr.gc.ca / Tel: 613-759-1228 / TTY: 613-773-2600
Bioinformaticien chef de la biodiversite interim, Direction générale des Science et de la technologie Agriculture et Agroalimentaire Canada / Gouvernement du Canada Iyad.Kandalaft@Agr.gc.ca / Tel: 613-759-1228 / TTY: 613-773-2600
-----Original Message----- From: galaxy-dev [mailto:galaxy-dev-bounces@lists.galaxyproject.org] On Behalf Of Shane Kelly Sent: July-28-15 8:23 AM To: galaxy-dev@lists.galaxyproject.org Subject: [galaxy-dev] I need some advice on what type of Galaxy server to implement
Hi I have been tasked with getting a Galaxy server up and running for a group at work.
1. No-one can tell me how many users (concurrent or otherwise) there will be 2. Most of the analyses will be NGS. 3. Tools will be developed in-house but we will use public domain tools also. 4. There will be a guy running the server/developing tools pretty much full time.
I have two favoured solutions at the moment:
1. A pipeline processor ( 64 Core, 512G Ram, with DAS of about 150TB ), and a Web server to act as frontend and database server, and another, smaller box for a total install of galaxy, but doing only the development work.
2. An all-in-one server with 128 Cores, 1TB ram, DAS storage of 150TB, and development work done on a VM.
Any input would be hepfull.
Thanks Shane ___________________________________________________________ Please keep all replies on the list by using "reply all" in your mail client. To manage your subscriptions to this and other Galaxy lists, please use the interface at: https://lists.galaxyproject.org/
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